血管生成

Sino Biological offers a comprehensive set of reagents for studying a variety of areas in angiogenesis process, involving angiogenesis growth factors, angiogenesis inhibitors, and proteases and adhesion molecules in angiogenesis. These high quality reagents include active proteins, highly specific antibodies (mouse Mabs, rabbit Mabs, rabbit Pabs), and cDNA clones.

血管生成相关产品索引

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血管生成粘附分子	血管生成细胞因子 / 趋化因子
血管形成生长因子及其受体	血管生成细胞外基质分子
血管生成素 / Tie	血管生成蛋白酶
集落刺激因子（CSF）及其受体	ADAM / ADAMTS
表皮生长因子(EGF)家族及其受体	半胱氨酸蛋白酶抑制剂
成纤维细胞生长因子（FGF）及其受体	激肽释放酶
血小板衍生生长因子（PDGF）及其受体	MMP
转化生长因子（TGF）- beta家族	TIMP
血管内皮生长因子（VEGF）及其受体	其它
其它

血管生成背景综述

Angiogenesis is the process of new blood vessel formation, which is an essential process during development, as well as wound healing. Angiogenesis is regulated by a very sensitive interplay of growth factors and inhibitors. Chemical stimulation of angiogenesis is performed by several growth factors, including FGFs (fibroblast growth factors), VEGFs (vascular endothelial growth factors), PDGFs, eprins, angiopoietins, TGF-beta and other. Angiogenesis inhibitors can be endogenous or exogenous (such as drug or a dietary component). Endogenous angiogenesis inhibitors may be interleukins, interferons, chemokines, or growth factor regulators.

Imbalance of angiogenesis stimulation and inhibition can lead to disease. In cancer, rheumatoid arthritis, and diabetic eye disease, excessive angiogenesis feeds diseased tissue and destroys normal tissue. Conversely, insufficient angiogenesis underlies conditions such as coronary heart disease, stroke and delayed wound healing, where inadequate blood-vessel growth leads to poor circulation and tissue death.

血管生成参考文献