白细胞分化抗原（CD）及其抗体

Sino Biological offers a comprehensive set of tools for Cluster of Differentiation (CD) molecule related research.These high-quality reagents include:

白细胞分化抗原（CD）产品索引

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B细胞CD抗原	单核细胞/巨噬细胞CD抗原
树突状细胞CD抗原	自然杀伤细胞CD抗原
粒细胞CD抗原	T细胞CD抗原
造血干细胞CD标志物	其它CD抗原
CD抗体

白细胞分化抗原（CD）背景综述

The cluster of differentiation (or cluster of designation), often abbreviated as CD, is a protocol used for the identification and investigation of cell surface molecules present on white blood cells (cells of the immunie system). The cluster of differentiation nomenclature was proposed for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes. Since then, the use of cluster of differentiation has expanded to many other cell types, and for humans CD is numbered up to 350 most recently (as of 2009).

The cluster of differentiation nomenclature describes different monoclonal antibodies from different sources that recognize identical antigens. The proposed surface molecule is assigned a CD number once two specific monoclonal antibodies are shown to bind to the molecule. A small letter w before the number designation stands for "workshop", which indicates that the CD designation is tentative

The cluster of differentiation is commonly used as cell markers, allowing cells to be defined based on what molecules are present on their surface. However, cluster of differentiation molecules are not merely markers on the cell surface. Cluster of differentiation molecules can act in numerous ways and are important for immune reactions of organisms. They often act as receptors or ligands important to the cell, initiating a signal cascade and altering the behavior of the cell. Some cluster of differentiation proteins do not play a role in cell signaling, but have other functions, such as cell adhesion.

白细胞分化抗原（CD）参考文献

1. Sakamoto K, et al. (2009) Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl. (31):58-63.
2. Lal S, et al. (2009) Using antibody arrays to detect microparticles from acute coronary syndrome patients based on cluster of differentiation (CD) antigen expression. Mol Cell Proteomics. 8(4):799-804.
3. Woolfson A, et al. (2006) The application of CD antigen proteomics to pharmacogenomics. Pharmacogenomics 7(5):759-71.