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Sino Biological offers a comprehensive set of tools for studying embryonic stem cells, including active proteins, highly specific antibodies (mouse Mabs, rabbit Mabs and rabbit Pabs) and cDNA clones.
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胚胎干细胞背景综述
Embryonic stem cells (ES) which are derived from the inner cell mass of the blastocyst are characterized by two distinctive properties: their pluripotency and their capability to self-renew themselves indefinitely. Embryonic stem cells are able to differentiate into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm, of which each can further differentiate to form a variety of cell types in the adult body. Embryonic stem cells are pluripotent and thus can generate all cell types in the body, while adult stem cells are multipotent and can only differentiate into a limited number of cell types. Because of their pluripotency and unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. Reprogramming of somatic cells with defined factors can be a resolution to the problem of allogeneic stem cell transplantation in embryonic stem cell therapies. Adult cells, which have been genetically reprogrammed to an embryonic stem cell–like state by being forced to express genes and factors important for maintaining the defining properties of embryonic stem cells, are referred to as induced pluripotent stem cells (iPSCs).
胚胎干细胞参考文献
- Thomson, et al. (1998) Blastocysts Embryonic Stem Cell Lines Derived from Human". Science 282(1145):1145-7.
- Ying, et al. (2003) BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3. Cell 115:281–292.
- Luong MX, et al. (2008) Human embryonic stem cell registries: value, challenges and opportunities. J Cell Biochem. 105(3):625-32.
- Gunaratne PH. (2009) Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells? Curr Stem Cell Res Ther. 4(3):168-77.
