Ephrin配体和受体酪氨酸激酶Eph亚族

Sino biological offers a comprehensive set of tools for research on ephrins and Eph receptors.

These high-quality reagents include:

Ephrin配体和受体酪氨酸激酶Eph亚族产品

Ephrin配体

Eph受体

Ephrin配体和受体酪氨酸激酶Eph亚族背景综述

Eph receptors belong to the receptor of tyrosine kinase (RTK) family which are a group of high affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. Eph receptors form the largest subgroup of the RTK family. Eph receptors interact with ephrin ligands, and their interaction would result in bi-directional signaling. There are currently 16 Eph receptors and 9 ephrins. Ephrins and Eph receptors play important roles in a number of biological processes, including cell migration, cell-cell interaction, cell morphology, angiogenesis and cancer. Recent studies also indicated other potential roles of Ephrins and Eph receptors in development. Ephrins and Eph receptors are emerging key players in synapse formation and plasticity in the central nervous system. Eph receptors are also expressed by cells found within the bone marrow microenvironment, including osteoclasts and osteoblasts, and there is increasing evidence to implicate this family of receptors in the control of normal and pathological bone remodeling.

Eph receptors are divided into two classes, based upon their interaction with ephrinA or ephrinB ligands. Eph receptors that bind to ephrinA ligands are referred to as EphA, and that bind to ephrinB ligands are referred to as EphB. But there is exception of EphA4 that can bind to ephrinA and ephrinB ligands, and ephrinA5 that can also bind to EphB2.

Ephrin配体和受体酪氨酸激酶Eph亚族参考文献