表皮生长因子(EGF)家族及其受体

Sino biological offers a comprehensive set of tools for research on epidermal growth factor family ligands and their receptors.

These high-quality reagents include:

表皮生长因子(EGF)家族及其受体产品

EGF家族配体

EGF受体家族

表皮生长因子(EGF)家族及其受体背景综述

EGF (epidermal growth factor) is the founding member of the EGF family of proteins, which also include Amphiregulin (AREG), Betacellulin (BTC), Epiregulin (EPR), HB-EGF, Neuregulins, and others. Members of EGF family have highly similar structural and functional characteristics. They have at least one common structural motif, the EGF domain, which consists of six conserved cysteine residues forming three disulfide bonds. The main structure of EGF domain is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. The activity of EGF family members is mediated by the EGFR/ErbB receptor tyrosine kinases. Members of the EGFR/ErbB family are made up of an extracellular region or ectodomain that contains approximately 620 amino acids, a single transmembrane spanning region and a cytoplasmic tyrosine kinase domain.

EGF plays an important role in the regulation of cell growth, proliferation, and differentiation EGF acts by binding to EGF receptor (EGFR) on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor, and initiates a signal transduction cascade. As a result a variety of biochemical changes take place within the cell, including increased intracellular calcium levels, glycolysis and protein synthesis and transcription of certain genes, which ultimately lead to DNA synthesis and cell proliferation. Members of EGF family are known to be involved in tumor formation, and the mediations of EGF therapy are so far mainly based on inhibiting the EGF receptor.

表皮生长因子(EGF)家族及其受体参考文献