IL-10/干扰素家族

白介素产品索引

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白介素及其受体
IL-1超家族和IL-1R/TLR家族	IL-12家族及其受体
IL-6家族及其受体	IL-17家族及其受体
IL-10/干扰素家族	其它白介素及受体
白介素及其受体的抗体

IL-10/干扰素家族产品索引

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IL-10家族配体

IL-10^*	IL-22^*	IL-28A / IFN lambda 2^*
IL-19^*	IL-24^*	IL-28B / IFN lambda 3^*
IL-20^*	IL-26^*	IL-29 / IFN lambda 1^*

干扰素

IFNA4 / IFN alpha 4B	IFNA8 / IFN alpha B2^*	IFN omega / IFNW
IFNA5 / IFN alpha 5	IFNA10 / IFN alpha C^*
IFNA7 / IFN alpha J1^*	IFN beta / IFNB

IL-10/干扰素家族受体 & 调节剂

BLIMP1^*	IL-10RA / CDw210a^*	IL-22RA2 / IL-22BP
JAK^*	IL-10RB / CDw210b	Limitin^*
IFNAR1	IL-20RA	STAT2^*
IFNGR1 / CD119	IL-22R / IL22RA1	STAT3^*

IL-10/干扰素家族背景综述

Interleukin-10 (IL-10 or IL10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is the prototypic member of the IL-10 cytokine family, including IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10 shares use of IL-10 receptor 2 (IL-10R2) in cell signaling with other members of this family (L-22, IL-26) and interferon-like molecules (limitin, L-28A, IL-28B, IL-29).

Interferons, which are made and released by the cells of most vertebrates in response to the presence of pathogens — such as viruses, bacteria, or parasites, or tumor cells, play critical role in host defense mechanisms. Based on the type of receptor through which they signal, human interferons have been classified into three major types: interferon type I, interferon type II and interferon type III.

The IL-10 family, interferons and interferon-like molecules constitute the Class 2 alpha-helical cytokines, which initiates a broad and varied array of signals that induce cellular antiviral states, modulate inflammatory responses, inhibit or stimulate cell growth, produce or inhibit apoptosis, and affect many immune mechanisms.

IL-10/干扰素家族参考文献

Pestka S, et al. (2004) Interleukin-10 and related cytokines and receptors. Annu Rev Immunol. 22:929-79.
Grütz G., et al. (2005) New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leukoc Biol. 77(1):3-15.
Vivier E, et al. (2009) Regulatory natural killer cells: new players in the IL-10 anti-inflammatory response. Cell Host Microbe. 6(6):493-5.
DU HW, et al. (2009) The effects of adipose-derived stem cell transplantation on the expression of IL-10 and TNF-alpha after cerebral ischaemia in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 25(11):998-1001.