白介素及其受体

Sino biological offers high-quality reagents for research on interleukins and their receptors.

These high-quality reagents include:

白介素及其受体产品索引

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IL-1超家族和IL-1R/TLR家族	IL-12家族及其受体
IL-6家族及其受体	IL-17家族及其受体
IL-10/干扰素家族	其它白介素及受体
白介素及其受体的抗体

白介素背景综述

Interleukins are a group of cytokines that were first seen to be expressed by leukocytes. The term interleukin describes a variety of polypeptides that act specifically as mediators between leucocytes. However, the name interleukin is something of a relic, since it has been found that interleukins are produced by a wide variety of body cells. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. The function of the immune system depends in a large part on interleukins. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Rare deficiencies of a number of Interleukins have been described, all featuring autoimmune diseases or immune deficiency.

The majority of interleukin cytokines can be divided into specific families based on structure and function. The 3-dimensional structure of the mature forms of each member of the human interleukin-1 superfamily is composed of 12-14 β-strands producing a barrel-shaped protein. The cytokines of interleukin-1 superfamily are key molecules both in the innate and in the adaptive immune response. Inclusion in the interleukin-6 family is based on a helical cytokine structure, shared receptor subunit makeup and activation of the signal transducing receptor protein glycoprotein 130 (gp130). The Interleukin-12 (IL-12, IL12) family cytokines, including IL-12, IL-23, IL-27 and IL-35, are key players in the regulation of T cell responses. All members of the IL-17 family have a similar protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape. There are still other interleukin molecules, which are currently not included in a defined family, such as, IL-13, IL-16, IL-32, IL-34, etc.