凝集素

Sino biological offers a comprehensive set of tools for lectin related research.

These high-quality reagents include:

粘附分子产品索引

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粘附分子
钙粘着蛋白超家族	整联蛋白
细胞粘附分子	凝集素
封闭素	其它粘附分子
细胞外基质及其相关分子

凝集素产品

C型凝集素家族

半乳糖凝集素

唾液酸结合性免疫球蛋白样凝集素(SIGLEC)

选择素

其它凝集素

凝集素背景综述

Lectins are a group of proteins that are capable of specific recognition of and reversible binding to carbohydrate moieties. A lectin molecule contains at least two sugar-binding sites. Lectins may be soluble or membrane-bound proteins or glycoproteins, and are expressed in many types of organism. Lectins were first described in 1888 by Stillmark working with castor bean extracts. Although lectins were first discovered more than 100 years ago in plants, they are now known to be present ubiquitously in nature. Lectins typically agglutinate red blood cells and precipitate glycoconjugates. They have also been demonstrated to be antigenic. In animals, lectins function in many different biological processes, including cell adhesion, glycoprotein synthesis, endocytosis, and the control of protein levels in the blood. Lectins are also known to play important roles in the immune system by recognizing carbohydrates that are found exclusively on pathogens, or that are inaccessible on host cells. Examples are the lectin complement activation pathway and mannose binding lectin.

Lectins can be divided into several subgroups, including C-type lectin family, galectins, sialic acid binding Ig-like lectins (SIGLECs). Selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding. They bind to sugar moieties and so are considered to be a type of lectin.

凝集素参考文献