肿瘤坏死因子（TNF）超家族

Sino biological offers a comprehensive set of tools for research on the tumor necrosis factor (TNF) superfamily.

These high-quality reagents include:

肿瘤坏死因子（TNF）超家族产品

TNF超家族配体

TNF受体超家族

肿瘤坏死因子（TNF）超家族背景综述

The tumor necrosis factor (TNF) superfamily of cytokines activate signaling pathways for cell survival, death, and differentiation that orchestrate the development, organization and homeostasis of lymphoid, mammary, neuronal and ectodermal tissues. Members of the TNF superfamily act through Ligand-mediated trimerization, causing recruitment of several intracellular adaptors to activate multiple signal transduction pathways. recruitment of death domain (DD) containing adaptors such as Fas associated death domain (FADD) and TNFR associated DD (TRADD) can lead to the activation of a signal transduction pathway that induces apoptosis. While recruitment of TRAF family proteins can lead to the activation of transcription factors such as, NF-kappaB and JNK thereby promoting cell survival and differentiation as well as immune and inflammatory responses.

Inclusion in the TNF ligands and receptors is based on the sequence and structure. The TNF-related ligands are type II transmembrane proteins with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. The key feature in the receptors is a cysteine-rich domain (CRD) formed of three disulfide bonds surrounding a core motif of CXXCXXC creating an elongated molecule.

肿瘤坏死因子（TNF）超家族参考文献