Wnt信号通路

Sino Biological provides a comprehensive set of tools for studying Wnt Signaling Pathway, including active proteins, antibodies (mouse Mab, rabbit Mab and rabbit Pab) and cDNA clones.

Wnt信号通路相关产品索引

Please click the following links to find products that you are interested.

经典Wnt信号通路	Wnt信号通路配体
非经典Wnt信号通路	Wnt信号通路受体
Wnt信号通路抑制剂

Wnt信号通路背景综述

Wnt signaling pathway involves a large number of proteins that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. The canonical Wnt signaling pathway has been elucidated in vertebrate and invertebrate model systems. The canonical Wnt signaling pathway is induced when Wnt proteins bind to cell-surface receptors of the Frizzled family, causing the receptors to activate Dishevelled family proteins and ultimately resulting in a change in the amount of beta-catenin that reaches the nucleus. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Other Wnt signaling pathways (non- canonical Wnt signaling pathways) include the planar cell polarity (PCP) pathway, the Wnt/Ca2+ pathway, and other. Wnt signaling pathway has been discovered to be involved in cancer. Chronic activation of the Wnt signaling pathway has been implicated in the development of a variety of human malignancies, including hepatocellular carcinomas (HCCs), colorectal carcinomas, melanomas and uterine and ovarian carcinomas. In addition, the Wnt signaling pathway, as well as the Hedgehog and Notch pathways, is thought to be involved in the occurrence of cancer stem cell.

Wnt信号通路参考文献